胰肽由胰腺的F細胞分泌。一般而言,肽會降低膽囊的收縮功能,增加膽總管的張力,並抑制胰腺的內分泌功能。通常,在胃,腸,膽囊手術過程中,F細胞的腫瘤會被意外檢測到。其唯一表現可能是外周血中胰肽含量增加。儘管如此,當胰肽分泌決定了潰瘍綜合徵或胰腺霍亂綜合徵的發展時,仍有觀察到。基本上,胰肽的分泌伴隨著其他激素的形成,並且是任何胰島細胞瘤的標誌物。
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