Ginofort

Gynofort is a drug whose main active ingredient is butoconazole. Butoconazole belongs to the class of antifungal drugs and is commonly used to treat fungal infections in gynecology.

The drug is used in the form of a cream or vaginal tablets and can be recommended for the treatment of various fungal infections of the female genital organs, such as vaginal candidiasis (cracks and irritations around the vagina caused by yeast-like fungi Candida albicans), vaginal trophic candidiasis, bacterial vaginosis, coccogoriasis and others.

Butoconazole acts by destroying fungal cells or suppressing their growth and reproduction, which leads to the disappearance of the infection. When used correctly, Gynofort can help eliminate the symptoms of a fungal infection and speed up recovery. However, before using Gynofort, it is important to consult a doctor for a proper diagnosis and recommendations for use.

適應症 Ginoforta

1. Vaginal candidiasis (thrush): This is the most common use of Gynofort. Vaginal candidiasis is caused by the yeast-like fungus Candida albicans and presents with a variety of symptoms, including itching, burning, irritation in the vaginal area, and a thick, white, loose discharge.
2. Atrophic vaginitis: This is a condition in which the vaginal lining becomes thinner and more sensitive due to decreased estrogen, which can lead to the development of a yeast infection.
3. Bacterial vaginosis: Although butoconazole is primarily used to treat yeast infections, in some cases it may also be recommended to treat bacterial vaginosis, although this is a less common use.

發布表單

Gynofort containing butoconazole is usually available in the form of vaginal creams or suppositories. These forms allow the drug to be used directly inside the vagina to treat various vaginal infections, such as vaginal candidiasis (fissures or infections caused by yeast).

藥效學

Butoconazole belongs to the class of antimycotic (antifungal) drugs, it has a broad spectrum of activity against various fungal infections, including yeast-like fungi (for example, Candida spp.) and dermatophytes (fungi that cause dermatomycosis).

It acts by inhibiting the synthesis of ergosterol, an important component of the fungal cell membrane. This leads to disruption of the function of the cell membrane, growth of the fungus, its reproduction and, ultimately, death.

藥代動力學

1. Absorption: Butoconazole is usually administered vaginally as a cream or suppository. Once administered vaginally, it can be absorbed through the vaginal mucosa and resorbed into the systemic circulation. Absorption is usually low, and most of the butoconazole remains at the injection site, providing local action.
2. Metabolism: Butoconazole is metabolized in the liver. It undergoes metabolic transformations, as a result of which metabolites are formed, which can then be excreted from the body.
3. Excretion: Butoconazole and its metabolites are usually excreted from the body through the kidneys and bile.
4. Half-life: The half-life of butoconazole from the body may vary depending on the individual characteristics of the patient and the conditions of use of the drug.
5. Interactions with other drugs: Because butoconazole is administered topically, systemic interactions with other drugs are usually minor. However, it is important to consider possible interactions, especially if the patient is taking systemic antifungals or drugs that may affect liver or kidney function.

劑量和管理

1. Method of application:

   • Before using Ginofort, it is recommended to wash your hands thoroughly.
   • If the drug comes in the form of a cream, it should be applied inside the vagina using the applicator provided in the package. This is usually done while lying on your back or with your legs slightly bent.
   • If the drug comes in the form of suppositories (vaginal tablets), they should be inserted into the vagina as deeply as possible using the provided applicator or finger.

2. Dosage:

   • The dosage of Gynofort may vary depending on the severity of the infection and the doctor’s recommendations.
   • It is usually recommended to use one dose of cream or suppository daily, usually for 1-2 weeks.
   • The dosage can be adjusted by the doctor depending on the individual characteristics of the patient and the severity of the disease.

在懷孕期間使用 Ginoforta

The use of Gynofort (butoconazole) during pregnancy is generally considered safe for the treatment of vaginal candidiasis, especially in the second and third trimesters when the risk to the fetus is minimized due to topical application and limited absorption. However, as with any medicine, its use should be discussed with your doctor.

1. In one study, miconazole, which is similar in action to butoconazole, was shown to be effective and safe in the treatment of vaginal candidiasis during pregnancy, demonstrating high therapeutic and mycological cure rates in pregnant women (Weisberg, 1987).
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2. Updated data on the use of antifungals during pregnancy indicate that topical antifungals, including butoconazole, are used because of their limited absorption, which reduces the risk of exposure to the fetus (Pilmis et al., 2015).

It is important to consult a physician before starting treatment with Gynofort during pregnancy to ensure the safety and effectiveness of therapy taking into account individual circumstances.

禁忌

1. Hypersensitivity or allergic reaction: People with a known hypersensitivity to butoconazole or other components of the drug should avoid its use.
2. Pregnancy and breastfeeding: Pregnant women and women breastfeeding should consult their doctor before using Gynofort to evaluate the benefits of treatment versus the potential risks to the baby.
3. Children: The effectiveness and safety of Gynofort in children have not been established, so its use in children may be undesirable.
4. Systemic fungal infections: Gynofort is for topical use and is not suitable for the treatment of systemic fungal infections. If there is a systemic infection, you should consult a doctor to prescribe appropriate treatment.
5. Damage to the skin or mucous membranes: The use of Gynofort may be contraindicated if there is significant damage to the skin or mucous membranes at the site of application.

副作用 Ginoforta

1. Burns, itching, or irritation in the vaginal area: Some women may experience a temporary increase in symptoms such as itching, burning, or irritation in the vaginal area. This may be caused by a reaction to the drug itself or a reaction to a fungal infection.
2. Change in the color or odor of vaginal discharge: There may be a change in vaginal imbalance, which may result in a change in the color or odor of the discharge.
3. Skin Reactions: Some people may experience a skin reaction such as skin rash, redness, or swelling in the area of application.
4. Allergic reactions: In rare cases, serious allergic reactions such as hives, facial swelling, difficulty breathing and anaphylactic shock may occur. If signs of an allergic reaction occur, seek immediate medical attention.
5. Other rare side effects: Other side effects may occur, such as headache, nausea, lower abdominal pain, or diarrhea.

過量

Information about overdose of Gynofort (containing butoconazole) is limited because data on cases of overdose are rare or absent. However, in case of possible overdose, you should consult a doctor or medical facility for advice and treatment.

Since Gynofort is applied topically in the form of cream or suppositories, the likelihood of overdose is low. However, if the drug is swallowed or used in the wrong dose, undesirable effects may occur.

Symptoms of possible overdose may include increased side effects of the drug, such as irritation, burning, itching, or allergic reactions. If any unpleasant symptoms appear after using Gynofort, it is recommended to stop using the drug and seek medical help.

與其他藥物的相互作用

1. Other antifungal agents: When used in combination with other topical or systemic antifungal agents, an enhanced or competitive effect may occur, which may improve or worsen the effectiveness of treatment.
2. Metal-containing agents: Because butoconazole is an azole antifungal agent, it may interact with metal-containing agents such as aluminum, magnesium, calcium, and iron, which may reduce its effectiveness. It is recommended to avoid the simultaneous use of Gynofort with similar drugs or to take them with a time interval.
3. Medicines that affect vaginal pH: The use of drugs or products that change vaginal pH, such as soaps or douches, may change the effectiveness of butoconazole. It is recommended to consult a doctor before using such products during treatment with Gynofort.
4. Hormonal drugs: When using hormonal drugs, such as contraceptives or hormone replacement therapy, a slight effect on the effectiveness of butoconazole is possible. However, the effect on the practice of use is usually insignificant.

儲存條件

1. Temperature: It is generally recommended to store Gynofort at a temperature between 15°C and 30°C. This means that the drug must be protected from extreme temperatures, as well as from direct exposure to sunlight and heat sources.
2. Humidity: The drug should be stored in a dry place to avoid damage. High humidity can lead to deterioration in the quality of the drug.
3. Packaging: It is important to store Ginofort in its original packaging or in the container in which it was purchased. This will help prevent accidental exposure of the drug to light and moisture.
4. Accessibility for children: The drug should be kept out of the reach of children to avoid accidental use.